金屬和陶瓷的複合材料多半是用來做為整型外科及牙醫上的植入材料。但由於大多數的金屬如鈦、鈦合金及316L不銹鋼在和骨格組織直接結合時，並不是具有相當好的生物相容性，為了改善這個缺點，我們先將鈦線與316L不銹鋼纖維經鹼液處理及高溫熱處理後，再浸入模擬體液(SBF)中於表面成長似骨質磷灰石。在其反應中，中間產物可以引導似骨質磷灰石於金屬表面上成核生長，故似骨質磷灰石的生成狀態及化學結構都是我們觀測的主要重點。實驗結果顯示，要在鈦線與316L不銹鋼纖維外部生長似骨質磷灰石的最佳條件為：先以5M的NaOH水溶液鹼處理鈦線基材後，再以400℃進行熱處理，最後將鈦線與316L不銹鋼纖維浸入80℃ 1.5倍的模擬體液(SBF)中浸泡15天後，便可於金屬表面生成適量的似骨質磷灰石。似骨質磷灰石的主要成分為鈣與磷，且其鈣磷比為接近於人骨的1.69與1.1。
Polymer, Ceramic and metal are wildly applied in orthopedic and dental materials, However, most metal including titanium, titanium alloy and 316L stainless steel do not posses bioactivities to bond with bone tissue. For improving this weakness, we incubated titanium wire and 316L stainless steel fiber into the simulated body fluid (SBF) after alkaline and thermal treatments to form a bone-like apatite layer on it. With the reaction, the coating was formed on the surface of metal and it can induce apatite nucleus appear on the surface. The surface appearance was observed and the chemical constitution of bone-like apatite was examined. As the result show, when the titanium wire and 316L stainless steel fiber treated with 5M NaOH aqueous solution, subsequently heated at 400℃ and soaked into SBF at a temperature of 80℃ increase the possibility of nucleation of considerable quantities of bone-like hydroxyapatite. We also found the main components of both the HA structures were Ca and P, and the percentage Ca/P were 1.69 and 1.1, which is similar to that of a natural bone.
