聚麩胺酸與幾丁聚醣交聯固定之改質聚丙烯不織布敷材對大鼠傷口癒合之研究

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Title:	聚麩胺酸與幾丁聚醣交聯固定之改質聚丙烯不織布敷材對大鼠傷口癒合之研究 Study on the γ-PGA and ChitosanGrafted onto Polypropylene Nonwoven Fabrics for Wound Dressing used on Rat Dermal Wounds
Authors:	蔡念潔；王權泉；蘇慶華
Contributors:	紡工系
Keywords:	創傷敷材聚丙烯不織布聚麩胺酸幾丁聚醣 wound dressing polypropylene γ-Poly-glutamic acid chitosan
Date:	2010-03-01
Issue Date:	2012-05-16 12:57:31 (UTC+8)
Abstract:	本實驗以最佳比例之接枝率15%，於70℃固定1%聚麩胺酸（γ－PGA）30分鐘及固定3%幾丁聚醣18小時固定後之接枝改質聚丙烯不織布，進行對大鼠傷口癒合的研究，經實驗發現以眾麩胺酸及幾丁聚醣交聯固定所製得之改質不織布敷材確實對大鼠傷口有良好的癒合情況；經白兔皮膚刺激性試驗發現不會對白兔皮膚造成影響。另，在體外細胞毒性測試中，發現此最佳比例之敷材不具有毒性，因此可將此敷材做為傷口癒合之敷料。 In this experimentation, the modified of PP nonwoven fabric which the ratio of grafted is 15%, after immobilized 1 % γ-PGA to persist 30 minutes in 70℃ and immobilized 3% chitosan to persist in 18 hours, after this experimentation, the γ-PGA and chitosan grafted onto polypropylene nonwoven fabrics for wound dressing is helpful to rat wounds, and in dermal irritiation test, it have no influence to rabbits's skin. Furthermore, from in vitro of cytotoxicity test, this wound dressing has no toxicity, so we can use this to be a kind of wound dressing.
Relation:	華岡紡織期刊 17卷1期 P.56-68
Appears in Collections:	[Department of Textile Engineering ] Journal of the Hwa Gang Textile

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