Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals

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Title:	Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals
Authors:	Wu, S (Wu, Semon) Hsu, LA (Hsu, Lung-An) Teng, MS (Teng, Ming-Sheng) Lin, JF (Lin, Jeng Feng) Chang, HH (Chang, Hsien-Hsun) Chang, PY (Chang, Pi-Yueh) Hu, CF (Hu, Chiao-Feng) Ko, YL (Ko, Yu-Lin)
Contributors:	生科系
Keywords:	MATRIX-METALLOPROTEINASE (MMP)-9 LIPOPROTEIN CHOLESTEROL LEVELS ACUTE CORONARY SYNDROME C-REACTIVE PROTEIN HEALTHY-SUBJECTS TISSUE INHIBITOR REFERENCE RANGE PLASMA MMP-9 GENE
Date:	2010-12
Issue Date:	2011-12-12 14:25:49 (UTC+8)
Abstract:	Background: Circulating concentrations of matrix metalloproteinase 9 (MMP-9) are associated with cardiovascular disease mortality in patients with coronary artery disease. We investigated the determinants of MMP-9 concentrations by analyzing MMP-9 genotypes and risk factors for cardiovascular disease. Methods: A total of 596 individuals were recruited for this study. Six single nucleotide polymorphisms (SNP) with coverage of the MMP-9 gene region were analyzed; and two genotypes, rs3918242-TT and rs2274756-AA, which were in nearly complete linkage disequilibrium, were associated with higher MMP-9 values (p = 0.007 and p = 0.008, respectively). In age-and gender-adjusted regression models, MMP-9 concentrations were positively associated with the homeostasis model assessment of insulin resistance (HOMA-IR) index and triglyceride concentrations, fasting serum insulin, fasting plasma glucose, C-reactive protein, fibrinogen, and serum amyloid A. By multivariate analysis, rs2274756 genotypes, age, smoking status, fibrinogen and fasting plasma glucose concentrations were all independently associated with MMP-9 (p = 0.007, p = 0.033, p = 0.003, p = 0.013, and p = 0.012, respectively). Conclusions: The rs2274756-AA and rs3918242-TT genotypes, younger age, current smoking status and increased fasting plasma glucose, and fibrinogen concentrations were independently associated with high serum MMP-9 concentrations in Taiwanese individuals. Clin Chem Lab Med 2010;48:543-9.
Appears in Collections:	[Department of Biology ] journal articles

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