MIDDLE-AGED SUBJECTS WITH HABITUAL LOW-SPEED CYCLING EXERCISE HAVE GREATER MONONUCLEAR CELL RESPONSIVENESS AGAINST HUMAN HEPATITIS B VIRUS SURFACE ANTIGEN

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Title:	MIDDLE-AGED SUBJECTS WITH HABITUAL LOW-SPEED CYCLING EXERCISE HAVE GREATER MONONUCLEAR CELL RESPONSIVENESS AGAINST HUMAN HEPATITIS B VIRUS SURFACE ANTIGEN
Authors:	Hsieh, KC (Hsieh, Kuen-Chang) Chen, YY (Chen, Yu-Yawn) Jang, TR (Jang, Tsong-Rong) Chen, YJ (Chen, Yu-Jen)
Contributors:	運教所
Keywords:	RESPIRATORY-TRACT INFECTION NECROSIS-FACTOR-ALPHA HUMAN LEUKEMIC U937 IMMUNE FUNCTION PHYSICAL-ACTIVITY HEPATOCELLULAR-CARCINOMA MODERATE EXERCISE CYTO-TOXICITY ELDERLY-WOMEN REPLICATION
Date:	2010-12
Issue Date:	2011-12-12 09:20:55 (UTC+8)
Abstract:	Background: Whether middle-aged people with habitual cycling exercise (HCE) at low intensity in the morning have higher immunity against hepatitis B virus than sedentary controls (SCs) is a health issue in the elderly. Methods: Conditioned media (CM) were prepared by stimulating isolated human peripheral blood mononuclear cells (MNC) with phytohemagglutinin (PHA) or assessment of their inhibitory effects on hepatitis B surface antigen expression in human hepatoma Hep3B cells. Results: With the percent of maximal oxygen uptake at about 45.52% and percent of maximal heart rate at about 68.58% during a cycling exercise program in the present study, we considered HCE as an aerobic and a low to moderate exercise for the elderly. The concentrations of secreted cytokines such as interferon gamma, tumor necrosis factor a and interferon alpha were higher in the MNC-CM from the HCE group than from the SC group. The inhibitory rates of MNC-CM of the HCE group against hepatitis B surface antigen expression were higher than that of the SC group. In the same stimulating concentration of PHA (10 mu g/mL), the relative hepatitis B surface antigen expression in MNC-CM of the HCE group was 64.7% versus 81.5% of the SC group. The reduction in inhibitory rates in cytokine neutralization experiments suggests crucial roles of these cytokines for the inhibitory effect of HCE-PHA-MNC-CM against hepatitis B surface antigen expression. Conclusion: The results reveal that the immune response of MNC, which are stimulated by PHA to suppress hepatitis B surface antigen expression, is greater in middle-aged subjects with low-speed HCE than in sedentary subjects. [International Journal of Gerontology 2010; 4(2): 82-88]
Appears in Collections:	[Graduate Institute of Sport Coaching Science ] journal articles

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