文化大學機構典藏 CCUR:Item 987654321/20909
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/20909


    题名: Constituents isolated from Cordyceps militaris suppress enhanced inflammatory mediator's production and human cancer cell proliferation
    作者: Rao, YK (Rao, Yerra Koteswara)
    Fang, SH (Fang, Shih-Hua)
    Wu, WS (Wu, Wen-Shi)
    Tzeng, YM (Tzeng, Yew-Min)
    贡献者: 園生系
    关键词: Cordyceps militaris
    Phytoconstituents
    Inflammatory mediators
    Human cancer cells proliferation
    日期: 2010-09
    上传时间: 2011-12-09 11:03:38 (UTC+8)
    摘要: Aim of the study: The purpose of this study is to isolate the pure compounds from the extracts of Cordyceps militaris obtained through solid-state cultivation process, and evaluate their anti-inflammatory and anticancer properties.

    Materials and methods Silica gel column chromatographic purification of Cordyceps mantels extracts resulted in the isolation of 10 pure compounds (1-10) The compounds 1-10 were examined for their growth inhibitory properties against nitric oxide (NO), tumor necrosis factor (TNF)-alpha and interleukin (IL)-12 enhanced production from LPS/IFN-gamma-stimulated macrophages Additionally, the anti-proliferation effects of 1-10 on human cancer cell lines, colon (colon 205), prostate (PC-3), and hepatoma (HepG2) cells were also analyzed.

    Results: Compounds displayed potent growth inhibition on NO, TNF-alpha and IL-12 production with an IC(50) value of 7.5, 6 3. and 7 6 mu g/ml, respectively. A similar inhibitory trend on these inflammatory mediators was observed for 3, 7, 9 and 10 with an IC(50) values ranging from 10 8 to 17 2 mu g/ml. On the other hand, compounds 3 and 8 were potent anti-proliferative agents with an IC(50) value of 35.6 and 32.6 mu g/ml toward PC-3 and colon 205 cell lines, respectively The compounds 1 and 2 showed potent anti-proliferation in PC-3 and colon 205 cells, while only 3 displayed such effect in HepG2 cells

    Conclusion: The present study provides scientific supporting information for the ethnopharmacological use of Cordyceps militaris as an anti-inflammatory and anticancer agent. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
    显示于类别:[園藝暨生物技術學系] 期刊論文

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