文化大學機構典藏 CCUR:Item 987654321/20879
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    题名: Should helical tomotherapy replace brachytherapy for cervical cancer? Case report
    作者: Hsieh, CH (Hsieh, Chen-Hsi)
    Wei, MC (Wei, Ming-Chow)
    Hsu, YP (Hsu, Yao-Peng)
    Chong, NS (Chong, Ngot-Swan)
    Chen, YJ (Chen, Yu-Jen)
    Hsiao, SM (Hsiao, Sheng-Mou)
    Hsieh, YP (Hsieh, Yen-Ping)
    Wang, LY (Wang, Li-Ying)
    Shueng, PW (Shueng, Pei-Wei)
    贡献者: 運教所
    关键词: HEMORRHAGIC RADIATION PROCTITIS
    UTERINE CERVIX
    HYPERBARIC-OXYGEN
    SUCRALFATE ENEMAS
    EXTERNAL-BEAM
    THERAPY
    PROCTOSIGMOIDITIS
    COMPLICATIONS
    RADIOTHERAPY
    PROCTOPATHY
    日期: 2010-12
    上传时间: 2011-12-08 15:53:19 (UTC+8)
    摘要: Background: Stereotactic body radiation therapy (SBRT) administered via a helical tomotherapy (HT) system is an effective modality for treating lung cancer and metastatic liver tumors. Whether SBRT delivered via HT is a feasible alternative to brachytherapy in treatment of locally advanced cervical cancer in patients with unusual anatomic configurations of the uterus has never been studied.

    Case Presentation: A 46-year-old woman presented with an 8-month history of abnormal vaginal bleeding. Biopsy revealed squamous cell carcinoma of the cervix. Magnetic resonance imaging (MRI) showed a cervical tumor with direct invasion of the right parametrium, bilateral hydronephrosis, and multiple uterine myomas. International Federation of Gynecology and Obstetrics (FIGO) stage IIIB cervical cancer was diagnosed. Concurrent chemoradiation therapy (CCRT) followed by SBRT delivered via HT was administered instead of brachytherapy because of the presence of multiple uterine myomas with bleeding tendency. Total abdominal hysterectomy was performed after 6 weeks of treatment because of the presence of multiple uterine myomas. Neither pelvic MRI nor results of histopathologic examination at X-month follow-up showed evidence of tumor recurrence. Only grade 1 nausea and vomiting during treatment were noted. Lower gastrointestinal bleeding was noted at 14-month follow-up. No fistula formation and no evidence of haematological, gastrointestinal or genitourinary toxicities were noted on the most recent follow-up.

    Conclusions: CCRT followed by SBRT appears to be an effective and safe modality for treatment of cervical cancer. Larger-scale studies are warranted.
    显示于类别:[運動教練研究所] 期刊論文

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