Caffeic Acid Phenethyl Ester, an Antioxidant from Propolis, Protects Peripheral Blood Mononuclear Cells of Competitive Cyclists against Hyperthermal Stress

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题名:	Caffeic Acid Phenethyl Ester, an Antioxidant from Propolis, Protects Peripheral Blood Mononuclear Cells of Competitive Cyclists against Hyperthermal Stress
作者:	Chen, YJ (Chen, Yu-Jen) Lai, LY (Lai, Li-Yun) Chiang, J (Chiang, Jasson) Huang, AC (Huang, Ai-Chun) Chang, HH (Chang, Hen-Hong) Liao, HF (Liao, Hui-Fen) Jiang, CM (Jiang, Chii-Ming) Chan, JT (Chan, Jen-Te) Chen, YY (Chen, Yu-Yawn)
贡献者:	運動教練研究所
关键词:	caffeic acid phenethyl ester (CAPE) cyclist glutathione hyperthermia mononuclear cell
日期:	2009
上传时间:	2011-11-30 13:01:47 (UTC+8)
摘要:	Hyperthermal stress and resulting free radical generation is known to impair endurance capacity and immune cell redistribution during prolonged exercise. Caffeic acid phenethyl ester (CAPE), a phenolic compound purified from propolis, has many biological and pharmacological activities including antioxidation. To examine whether CAPE has protective effect against hyperthermal stress in athletes, we isolated peripheral blood mononuclear cells (MNC) from competitive cyclists and assessed their response to hyperthermia with or without CAPE pretreatment. We found that pretreatment of cyclists' MNC with CAPE (0, 1, 2, 4 mu g/mL) reversed or reduced hyperthermia-induced survival inhibition, necrosis, superoxide production, glutathione depletion, and intracellular superoxide burst in a dose-dependent manner. These results suggest that CAPE may enhance the hyperthermal tolerance in immune mononuclear cells of competitive cyclists.
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