Different bacteria species lipopolysaccharide co-exposure with Pseudomonas exotoxin A on multiple organ injury induction

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Title:	Different bacteria species lipopolysaccharide co-exposure with Pseudomonas exotoxin A on multiple organ injury induction
Authors:	Chu, YY (Chu, Ying-Yueh) Chuang, HL (Chuang, Hsiao-Li) Chiu, CC (Chiu, Chien-Chao) Chen, TH (Chen, Ter-Hsin) Chen, HHC (Chen, Hans Hsien-Chuan) Huang, YT (Huang, Yen-Te)
Contributors:	食營系
Date:	2009
Issue Date:	2011-11-28 15:09:34 (UTC+8)
Abstract:	The present study investigated the effect of different bacterial species lipopolysaccharide plus Pseudomonas exotoxin A (LPS/PEA) on the induction of multiple organ injury (MOI). Rats were injected with various LPS from Salmonella (SAE, SAT), E. coli (EB4, EB5), or P. aeruginosa (PAL) and PEA showed a greater mortality in the SAE/PEA and SAT/PEA groups. Histological alterations, serum enzymes, and cytokines changes were severer in the SAE/PEA group than the EB4/PEA or PAL/PEA group. EB4/PEA and PAL/PEA failed to induce MOI, even at the LPS doses increased up to 2-4- and 4-8-fold, respectively. Rats co-treated with Salmonella lipid A/PEA developed severer MOI than the E. coli lipid A/PEA. The results indicated the critical roles of MOI induction, which were related to LPS derived from appropriate bacterial species.</.
Appears in Collections:	[Department of Food and Nutrition ] journal articles

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