| 摘要: | 近年來因心血管疾病而死亡的人數持續上升，而高血脂是導致罹患心血管疾病的主要危險因子。因此，降低血脂可以預防心血管疾病。本實驗的主要目的為開發適合高血脂症病患食用包含了蕎麥、紫米、糙米、小米及大麥的混合穀物粥品粉末，混合穀物粉末（Mixed grain porridge powder；MG）是由中華穀類食品工業技術研究所（CGPRDI）提供。本實驗將80隻雄性倉鼠分為十組，每組八隻：正常飲食組（7 %的大豆油）、高油脂飲食組（12 %的大豆油及0.2 %的膽固醇）及高油脂飲食組混合四種不同比例穀物粥粉 （MG A, B, C and D 10% 或20% 取代玉米澱粉）。餵食飼料八週後，利用二氧化碳窒息法來犧牲實驗動物。我們利用自動血液生化分析儀來分析血清的三酸甘油酯（TG）、總膽固醇（TC）、高密度脂蛋白膽固醇（HDL-C）及低密度脂蛋白膽固醇（LDL-C），以及肝臟的TG及TC來探討混合穀物粥粉降血脂的功效。
MG A 20%、 MG C 20% 、MG D 10%及MG D 20%都能顯著的降低TG的濃度(P < 0.05)，而MG D 20%（降低43 %）能比他9組具有更佳的效果（p < 0.001）。 全部食用粥粉的組別都能顯著的降低血清TC及LDL-C，而所有實驗組的HDL-C、AST及ALT濃度互相無顯著差異。此實驗結果顯示了食用混合粥粉能夠有效的降低高油脂飲食倉鼠的血脂質，MG 20 %配方將來可用來開發成適合高血脂症病患食用的產品。
The number of death caused by cardiovascular disease (CVD) is remaining high in recent years, and the major risk factor of CVD is high blood lipid. Therefore, reducing blood lipid level is beneficial for CVD prevention. The aims of this study is to develop mixed grain porridge powder for patients with hyperlipidemia, the grains including buckwheat, black rice, brown rice and barley. Four mixed grains porridge powders were prepared by China Grain Products Research and Development Institute (CGPRDI) according to the commercial secret formulas. In this study, eighty hamsters were divided into 10 groups, including normal diet group (7 % soy bean oil), high-fat diet group (12 % soy bean oil and 0.2% cholesterol) and high-fat diets with 4 different mixed grains porridge powders (MG A, B, C and D, 10 % or 20 % replaced corn starch). Following 8-week diet feeding, these hamsters were sacrificed by carbon dioxide perfusion. Serum triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C),and high density lipoprotein -cholesterol (HDL-C) were measured by biochemical analyzer and he-patic TG, TC were also determined for evaluations of lipid lowering effects of mixed grains porridge powders.
The levels of TG are significant lowering in MG A 20 %, MG C 20 %, MG D 10 % (P < 0.05), and the lowering lipid effect of MG D 20 % (43 % reducing) is better than other groups (P < 0.001). All the levels of TC and LDL-C of MG group are diminished significantly. The serum HDL-C, AST and ALT levels of all experimental groups are not different from each other. This results suggest that all the mixed grains porridge powders can reduce blood lipid in hyperlipidemic hamsters. |
