毛將軍全草之化學成分研究

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Title:	毛將軍全草之化學成分研究
Authors:	林彥辰
Contributors:	化學系
Keywords:	毛將軍菊科艾納香屬
Date:	2010
Issue Date:	2011-10-20 10:45:23 (UTC+8)
Abstract:	摘要：毛將軍(Blumea hieracifolia (D. Don) DC.; Erigeron hieracifolium D. Don)屬於菊科(Compositae)艾納香屬植物，又名毛毡草、臭草。植物為多年生草本，全草有清熱解毒、涼血活血、解毒消腫、排膿止痛之效。用於治肺炎、腎臟炎、腸炎腹瀉、毒蛇咬傷等。本研究探討毛將軍之化學成分，風乾後之植物全草，以95%乙醇於55℃下抽取，所得之乙醇抽取物，分為二氯甲烷：丙酮(1:1)可溶與甲醇可溶兩部分，各部分利用管柱色層層析法分離純化，得到十四個化合物，經由質譜與核磁共振光譜分析法，確立化合物之構造，分別為blumealactone (1)、 salcolin A (tricin-4'-O-(erythro-β-guaiacylgl ycerylether)) (2)、 luteolin-7-O-β-D- glucoside (3)、luteolin (4)、tricin (5)、quercitin (6)、1,3,5-tri-O- caffeoylquinic acid (7)、3,5-di-O-caffeoylquinic acid methy ester (8)、3,5-di-O-caffeoylquinic acid (9)、4,5-di-O-caffeoylquinic acid (10)、3,4,5-tri-O-caffeoylquinic acid (11)、2N-[2'-hydroxy-tetraconsanoyl] -8(Z)-octadecene-1,3,4-triol (12)、2N[1-O-(β-D-glucopyanosyl)-2'-hydroxy-tetracosanoyl]-8(Z)-octadecene-1,3,4-triol (13)、friedelin (14)，其中化合物1為新化合物blumealactone。 Blumea hieracifolia (D. Don) DC. (Compositae) distributed in the whole territory of Taiwan, is a folk for the treatment of lung disease, kidney disease, gastroenteritis, diarrhea, etc. In order to study the chemical constituents of this plant, extraction and isolation were proceeded. The EtOH extract of the whole herbs was treated with CH2Cl2－Me2CO (1:1) and then MeOH. Two soluble portions were separated and purified by a combination of several chromatographic techniques, which led to the isolation of one new compound. blumealactone (1) with other thirteen compounds which were identified as salcolin A (tricin-4'-O-(erythro-β-guaiacylglyceryl ether)) (2)、 luteolin-7-O-β-D- glucoside (3)、luteolin (4)、tricin (5)、 quercitin (6)、1,3,5-tri-O- caffeoylquinic acid (7)、3,5-di-O-caffeoylquinic acidmethy ester (8)、3,5-di-O-caffeoylquinic acid (9)、4,5-di-O-caffeoylquinic acid (10)、3,4,5-tri-O-caffeoylquinic acid (11)、2N-[2'-hydroxy-tetraconsanoyl]-8(Z) -octadecene-1,3,4-triol (12)、2N[1-O-(β-D-glucopyanosyl)-2'-hydroxy- tetracosanoyl]-8(Z)-octadecene-1,3,4-triol (13)、friedelin (14). The structures of these compounds were elucidated using spectroscopic methods and compared their spectral data with those in literature.
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