文化大學機構典藏 CCUR:Item 987654321/18259
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 47126/50992 (92%)
造访人次 : 13860563      在线人数 : 272
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于CCUR ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/18259


    题名: Stability of Furosemide, Nadolol and Propranolol Hydrochloride in Extemporaneously Compounded Powder Packets From Tablets
    作者: 高雅慧
    林翠蓉
    黃燕棻
    蔡瑞真
    贡献者: 財金系
    关键词: Extemporaneous compounding
    Powder packet
    Stability
    日期: 2000-02
    上传时间: 2010-12-23 10:45:47 (UTC+8)
    摘要: The stability of furosemide, nadolol, and propranolol hydrochloride in extemporaneously compounded single-dose powder packets was studied. The powders prepared from crushing and triturating commercial tablets with acetylcysteine granules, lactose powder, or lactofermin tablets were divided and packed into single doses using a packing system in the hospital pharmacy. The packets were stored under ambient conditions, and samples were removed at 0, 1, 2, 3, and 4 weeks for assay of drug concentrations by stability-indicating high-performance liquid chromatography. The results demonstrated that the concentration of nadolol in the samples with any of the three diluents remained within 90 % of initial concentration throughout the study period under storage conditions. Furosemide and propranolol hydrochloride were stable for up to 4 weeks (more than 90 % of initial concentration remaining) with lactose or lactofermin tablets employed as diluents but, furosemide was stable with acetylcysteine granules for only 7 days, and less than 90 % initial concentration of propranolol hydrochloride remained in the powders following one week of storage. In addition, the packing process significantly reduced the drug concentrations in both furosemide and propranolol hydrochloride powders diluted with acetylcysteine granules. The acidic nature and ingredients in acetylcysteine granules may have accelerated the degradation of both furosemide and propranolol hydrochloride. It is therefore recommended that acetyl cysteine granules should be avoided in the extemporaneous compounding of pediatric powders for both drugs.
    關聯: The Chinese Pharmaceutical Journal 52卷1期 P.51-58
    显示于类别:[財務金融學系 ] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML268检视/开启


    在CCUR中所有的数据项都受到原著作权保护.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈