Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-kappa B induced oxidative stress and inflammation

文化大學機構典藏 CCUR > 體育運動健康學院 > 運動教練研究所 > 期刊論文 > Item 987654321/20549

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/20549

题名:	Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-kappa B induced oxidative stress and inflammation
作者:	Chiang, J (Chiang, Jasson) Liou, KT (Liou, Kuo-Tong) Shen, YC (Shen, Yuh-Chiang) Wang, YH (Wang, Yea-Hwey) Hou, YC (Hou, Yu-Chang) Chen, CC (Chen, Chien-Chih) Liao, JF (Liao, Jyh-Fei) Yu, MC (Yu, Min-Chien) Juan, CW (Juan, Chi-Wen)
贡献者:	運動教練研究所
关键词:	Eccentric exercise Honokiol Skeletal muscle Nuclear factor kappa-B Cytokine Inflammation Nitrotyrosylation Oxidative stress Leukocyte infiltration Poly-ADP-ribose-polymerase
日期:	2009
上传时间:	2011-11-30 15:36:13 (UTC+8)
摘要:	Honokiol, a bioactive component isolated from the Chinese herb Magnolia officinalis, is known for its potent antioxidative and anti-inflammatory effects. To study whether honokiol can protect skeletal muscle from sports injuries, we set up an eccentric exercise bout protocol for rats consisting of downhill running on a treadmill and examined the effect of oral administration of honokiol at 1 h before eccentric exercise at a dose of 5 mg/kg on day 1 (HK5x1) or 7 mg/kg/day for 5 consecutive days (HK1x5). Eccentric exercise was implemented for 3-5 consecutive days, and induced remarkable tissue damage. This damage was associated with an increase in serum creatine levels, increase in protein nitrotyrosylation, poly-ADP-ribose-polymerase (PARP) upregulation, lipid peroxidation, and leukocyte infiltration. The degree of muscle damage also paralleled dramatic gene expression for cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and inflammation-associated cytokines (interleukin (IL)-1 beta, IL-6, tumor necrosis factor-a, and monocyte chemoattractant protein-1), possibly through activation of nuclear factor kappa-B (NF-kappa B), a crucial proinflammatory transcription factor. Both honokiol treatments (HK5x1 and HK1x5) significantly ameliorated eccentric exercise-induced muscle damage as revealed by suppression of cell fragmentation, protein nitrotyrosylation and PARP upregulation, as well as reductions in lipid peroxidation and leukocyte infiltration, possibly through downregulating gene expression for COX-2, iNOS, and the proinflammatory cytokines by modulation of NF-kappa B activation. In conclusion, the present study demonstrates for the first time that honokiol exhibits protective effects against eccentric exercise-induced skeletal muscle damage in rats, probably by modulating inflammation-mediated damage to muscle cells. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
显示于类别:	[運動教練研究所] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	665	检视/开启

在CCUR中所有的数据项都受到原著作权保护.

数据加载中.....